±¬ÁÏÍõ

Faculty of Medicine and Health

false

/content/dam/corporate/images/medicine-and-health/research/research-centres/other-research-groups-and-projects/jenny-wang-lab-banner.jpg

50%

Cancer and Stem Cell Laboratory

Targeting malignant stem cells towards a cure for blood cancer
  • /medicine-health/industry-and-community/industry-partnerships/partnership-enquiries.html Partner with us
  • /medicine-health/industry-and-community/support-us.html Support us

m-hero--style-3

1280.1280.jpeg 1280w, 800.450.2x.jpeg 1600w, 440.248.2x.jpeg 880w, 220.124.2x.jpeg 440w

false

Our lab is investigating how healthy stem cells are converted into malignant stem cells and is developing effective therapies to destroy cancer stem cells without harming healthy stem cells for curing deadly blood cancer.

Our research

Blood cancer could be the leading form of cancer deaths by 2035, according to Australia's first strategic action plan.

Acute myeloid leukemia is the deadliest form of blood cancer with a high rate of treatment failure and relapse. Relapsed leukemia has an extremely poor survival of <10%.

Chemotherapy is the first-line treatment for the deadly blood cancer. However, it is not effective against dormant (inactive) malignant stem cells that consequently regenerate a more aggressive leukemia using their unique tumorigenic/stemness characteristics. Ablating leukemia stem cells is critical for successful anticancer therapy.

Over the past 9 years, our lab has generated a body of knowledge in the discovery of therapeutic targets essential for leukemia stem cell characteristics and established evidence of therapeutic efficacy for clinical trials. Most of our research has been published in top scientific journals including Cancer Cell and Blood.

In partnership with industry and close collaboration with clinicians, we are currently converting our research breakthroughs into innovative stem cell-targeted therapies in clinical trials, which will directly benefit patients with the deadly blood cancer.

  • Leukemia stem cell biology
  • Targeted therapy (incl. immunotherapy and CAR-T cell therapy)
  • Preclinical drug testing
  • Functional genomics and epigenetics
  • Signaling pathways
  • Cancer metabolism
  • Cellular barcoding
  • Single-cell multiomics and CUT&Tag

  • National Health and Medical Research Council (NHMRC)
  • Cancer Australia
  • Leukaemia Foundation
  • Cancer Council
  • Tour de Cure
  • Industry

  • Teng L, Feng YC, Guo ST, Wang PL, Wang SX, Zhang SN, Qi TF, La T, Zhang YY, Zhao XH, Zhang D, Wang JY, Shi Y, Li JM, Cao H, Liu T, Thorne RF, Jin L, Shao F, Zhang XD.ÌýThe pan-cancer lncRNA PLANE regulates an alternative splicing program to promote cancer pathogenesis. Nature Communications. 2021. 12:3734.Ìý(IF 14.92)
  • Chen J, Nelson C, Wong M, Tee AE, Liu PY, La T, Fletcher JI, Kamili A, Mayoh C, Bartenhagen C, Trahair TN, Xu N, Jayatilleke N, Wong-Erasmus M, Peng H, Atmadibrata B, Cheung BB, Lan Q, Bryan TM, Mestdagh P, Vandesompele J, Combaret V, Boeva V, Wang JY, Janoueix-Lerosey I, Cowley MJ, MacKenzie KL, Dolnikov A, Li J, Polly P, Marshall GM, Reddel RR, Norris MD, Haber M, Fischer M, Zhang XD, Pickett HA, and Liu T.ÌýTargeted therapy of TERT-rearranged neuroblastoma with BET bromodomain inhibitor and proteasome inhibitor combination therapy.ÌýClinical Cancer Research. 2021. 27(5):1438-1451. (IF 12.53)
  • Lan Q, Liu PY, Bell JL, Wang JY, Hüttelmaier S, Zhang XD, Zhang L, Liu T.ÌýThe emerging roles of RNA m6A methylation and demethylation as critical regulators of tumorigenesis, drug sensitivity, and resistance.ÌýCancer Research. 2021.Ìý81(13):3431-3440.Ìý(IF 12.7)
  • Salik B, Yi H, Hassan N, Santiappillai N, Vick B, Connerty P, Duly A, Trahair T, Woo AJ, Beck D, Liu T, Spiekermann K, Jeremias I, Wang J, Kavallaris M, Haber M, Norris MD, Liebermann DA, D'Andrea RJ, Murriel C, Wang JY.ÌýTargeting RSPO3-LGR4 signaling for leukemia stem cell eradication in acute myeloid leukemia.ÌýCancer Cell. 2020. 38:263-278.Ìý(IF 31.74)
  • Hassan N, Yang J and Wang JY. An improved protocol for establishment of AML patient-derived xenograft models.ÌýSTAR Protocols. 2020. 1(3):100156. doi: 10.1016/j.xpro.2020.100156Yang J, Hassan N, Chen SXF, Datuin J, Wang JY.ÌýSelf-renewal pathways in acute myeloid leukemia stem cells. In Pier Paolo Piccaluga (Eds.), Acute Leukemias.ÌýRijeka, Croatia: InTech Publishers. Book Chapter. 2020.Ìýdoi:10.5772/intechopen.94379.
  • Lynch JR, Salik B, Connerty P, Vick B, Leung H, Pijning A, Jeremias I, Spiekermann K, Trahair T, Liu T, Haber M, Norris MD, Woo AJ, Hogg P, Wang J and Wang JY.ÌýJMJD1C-mediated metabolic dysregulation contributes to HOXA9-dependent leukemogenesis.ÌýLeukemia. 2019. 33:1400-1410. (IF 11.53   
  • Gonzales-Aloy E, Connerty P, Salik B, Liu B, Woo AJ, Haber M, Norris MD, Wang J and Wang JY.ÌýmiR-101 suppresses the development of MLL-rearranged acute myeloid leukemia.ÌýHaematologica. 2019. 104:296-299.Ìý(IF 9.94)
  • Wong M, Sun Y, Xi Z, Milazzo G, Poulos RC, Bartenhagen C, Bell JL, Mayoh C, Ho N, Tee AE, Chen X, Li Y, Ciaccio R, Liu PY, Jiang CC, Lan Q, Jayatilleke N, Cheung BB, Haber M, Norris MD, Zhang XD, Marshall GM, Wang JY, Hüttelmaier S, Fischer M, Wong JWH, Xu H, Giovanni Perini, Qihan Dong, George RE, Liu T.ÌýJMJD6 is a tumorigenic factor and therapeutic target in neuroblastoma.ÌýNature Communications. 2019. 10:3319. (IF 14.92)
  • Liu P, Tee A, Milazzo G, Hannan K, Maag J, Mondal S, Atmadibrata B, Bartonicek N, Peng H, Ho N, Mayoh CM, Ciaccio R, Sun Y, Henderson M, Gao J, Everaert C, Hulme A, Cheung B, Shi L, Wang JY, Simon T, Fischer M, Zhang XD, Marshall G, Norris M, Haber M, Vandesompele J, Li J, Mestdagh P, Hannan R, Dinger M, Perini G, and Liu T.ÌýThe long noncoding RNA lncNB1 promotes tumorigenesis by interacting with ribosomal protein RPL35.ÌýNature Communications. 2019.Ìý10:5026.Ìý(IF 14.92)
  • Woo AJ, Patry C, Ghamari A, Pregernig G, Zheng K, Piers T, Hibbs M, Li JK, Fidalgo M, Wang JY, Lee J, Leedman PJ, Wang J, Fraenkel E, and Cantor AB.ÌýZfp281 (ZBP-99) plays a functionally redundant role with Zfp148 (ZBP-89) during erythroid development.ÌýBlood Advances. 2019. 3:2499-2511. (IF 6.799)
  • Wong MK, Tee AE, Milazzo G, Bell JL, Poulos RC, Atmadibrata B, Sun Y, Jing D, Ho N, Ling D, Liu PY, Zhang XD, Hüttelmaier S, Wong JW, Wang JY, Polly P, Perini G, Scarlett CJ, Liu T.ÌýThe histone methyltransferase DOT1L promotes neuroblastoma by regulating gene transcription.ÌýCancer Research. 2017.Ìý77:2522-2533. (IF 12.7)
  • Sun Y, Atmadibrata B, Yu D, Wong MKK, Liu B, Ho N, Ling D, Tee AE, Wang JY, Mungrue IN, Liu PY, Liu T.ÌýUp-regulation of LYAR induces neuroblastoma cell proliferation and survival.ÌýCell Death & Differentiation. 2017.Ìý24:1645-1654.Ìý(IF 15.83)
  • Lynch JR, Yi H, Casolari DA, Voli F, Gonzales-Aloy E, Fung TK, Liu B, Brown A, Liu T, Haber M, Norris MD, Lewis ID, So CWE, D’Andrea RJ, Wang JY.ÌýGaq signaling is required for the maintenance of MLL-AF9 induced acute myeloid leukemia.ÌýLeukemia. 2016. 30:1745-1748. (IF 11.53)
  • Lynch JR, Wang JY.ÌýG protein-coupled receptor signaling in stem cells and cancer.ÌýInt J Mol Sci. 2016. 17:707.Ìý(IF 5.92)
  • Dietrich PA, Yang C, Leung HH, Lynch JR, Gonzales E, Liu B, Haber M, Norris MD, Wang J, Wang JY.ÌýGPR84 sustains aberrant β-catenin signaling in leukemic stem cells for maintenance of MLL leukemogenesis.ÌýBlood. 2014. 124:3284-3294. (IF 23.63)
  • Lane SW*, Wang JY*, Lo Celso C*, Ragu C, Bullinger L, Sykes SM, Ferraro F, Shterental S, Lin CP, Gilliland DG, Scadden DT, Armstrong SA, Williams DA.ÌýDifferential niche and Wnt requirements during acute myeloid leukemia progression.ÌýBlood. 2011.Ìý118:2849-2856.Ìý*equal contribution (IF 23.63)
  • Wang JY, Krivtsov AV, Sinha AU, North TE, Goessling W, Feng Z, Zon LI, Armstrong SA.ÌýThe Wnt/β-catenin pathway is required for the development of leukemia stem cells in AML.ÌýScience. 2010.Ìý327:1650-1653.Ìý(IF 47.73)
  • Wang JY, Armstrong SA.ÌýCancer: inappropriate expression of stem cell programs.ÌýCell Stem Cell. 2008. 2: 297-299. (IF 24.63)
  • Wang JY, Armstrong SA.ÌýGenome-wide SNP analysis in cancer: leukemia shows the way.ÌýCancer Cell. 2007. 11:308-309. (IF 31.74)
  • Krivtsov AV, Twomey D, Feng Z, Stubbs MC, Wang JY, Faber J, Levine JE, Wang J, Hahn WC, Gilliland DG, Golub TR, Armstrong SA.ÌýTransformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9.ÌýNature. 2006. 442:818–822. (IF 49.96)

Our people

  • Associate Professor 

Useful links

50

automatic

Link

Contact us

Email
jenny.wang@sydney.edu.au

Mailing address
Royal North Shore Hospital grounds
Kolling Institute of Medical Research
10 Westbourne Street (corner of Reserve Road & Westbourne Street)
St Leonards NSW, 2065